| Is human giardiasis caused by two different Giardia species? | |
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MedLine Citation:
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PMID: 21468219 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have recently sequenced the genome of the human Giardia intestinalis assemblage B isolate GS.1 comparisons to the earlier sequenced genome of the human assemblage A isolate WB showed that the average amino acid identity in 4,300 orthologous proteins was only 78%. Here we discuss these results in the light of new genome sequencing data from the hoofed-animal assemblage E (isolate P15, isolated from a pig) and further characterization of assemblage A and B isolates from humans. There is a highly conserved set of core genes (4,557 genes, 91% of genome) common to all isolates. The largest genomic differences are found in variable, Giardia-specific gene families and a large number of chromosomal rearrangements were detected, even between different chromosomes. Surprisingly, the assemblage E and A isolates are more similar at the amino-acid level than the two human isolates are to each other. This strengthens our earlier data suggesting that humans are infected by two different species of Giardia. |
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Authors:
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Jon Jerlström-Hultqvist; Johan Ankarklev; Staffan G Svärd |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Gut microbes Volume: 1 ISSN: 1949-0984 ISO Abbreviation: - Publication Date: 2010 11 |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101495343 Medline TA: Gut Microbes Country: - |
Other Details:
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Languages: ENG Pagination: 379-382 Citation Subset: - |
Affiliation:
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Department of Cell and Molecular Biology; BMC; Uppsala University; Uppsala, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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