Document Detail


Is human giardiasis caused by two different Giardia species?
MedLine Citation:
PMID:  21468219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recently sequenced the genome of the human Giardia intestinalis assemblage B isolate GS.1 comparisons to the earlier sequenced genome of the human assemblage A isolate WB showed that the average amino acid identity in 4,300 orthologous proteins was only 78%. Here we discuss these results in the light of new genome sequencing data from the hoofed-animal assemblage E (isolate P15, isolated from a pig) and further characterization of assemblage A and B isolates from humans. There is a highly conserved set of core genes (4,557 genes, 91% of genome) common to all isolates. The largest genomic differences are found in variable, Giardia-specific gene families and a large number of chromosomal rearrangements were detected, even between different chromosomes. Surprisingly, the assemblage E and A isolates are more similar at the amino-acid level than the two human isolates are to each other. This strengthens our earlier data suggesting that humans are infected by two different species of Giardia.
Authors:
Jon Jerlström-Hultqvist; Johan Ankarklev; Staffan G Svärd
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Gut microbes     Volume:  1     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2011-07-28     Completed Date:  2012-09-27     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  IM    
Copyright Information:
© 2010 Landes Bioscience
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA, Protozoan / chemistry,  genetics*
Gene Rearrangement
Genes, Protozoan
Genome*
Genotype
Giardia / classification*,  genetics*,  isolation & purification
Giardiasis / parasitology*,  veterinary*
Humans
Chemical
Reg. No./Substance:
0/DNA, Protozoan
Comments/Corrections

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