Document Detail

The human fetal prolactin and estradiol levels, and their correlationship.
MedLine Citation:
PMID:  6431636     Owner:  NLM     Status:  MEDLINE    
Serum prolactin and estradiol-17 beta levels were determined in umbilical cord sera obtained from 33 preterm, 118 full-term and 11 anencephalic infants and in peripheral sera obtained from 5 neonates. Prolactin levels increased from mid-gestation toward term, and markedly decreased after birth. Those in anencephalic infants (253 +/- 86 ng/ml, mean +/- S.D.) were lower than in full-term infants (324 +/- 119 ng/ml), but the difference was not statistically significant. We also performed thyroid-releasing-hormone (TRH) (50-200 micrograms) test on 5 anencephalic infants, but significant changes of serum prolactin levels were not found. Estradiol-17 beta levels in anencephalic infants were significantly lower than those in full-term infants. There was a significant positive correlation between cord prolactin and estradiol-17 beta levels in full-term infants. These results suggest one of the control factors for human fetal pituitary prolactin secretion is estrogen, and hypothalamic factors are not so important.
T Fukaya; N Furuhashi; O Shinkawa; H Kono; T Takahashi; M Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  143     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-09-18     Completed Date:  1984-09-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
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MeSH Terms
Anencephaly / blood
Estradiol / blood*
Fetal Blood / analysis*
Gestational Age
Infant, Newborn
Infant, Premature
Prolactin / blood*
Thyrotropin-Releasing Hormone / diagnostic use
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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