| The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. | |
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MedLine Citation:
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PMID: 11178117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex. |
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Authors:
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R Brouwer; G J Pruijn; W J van Venrooij |
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Publication Detail:
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Type: Journal Article; Review Date: 2000-12-20 |
Journal Detail:
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Title: Arthritis research Volume: 3 ISSN: 1465-9905 ISO Abbreviation: Arthritis Res. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100913255 Medline TA: Arthritis Res Country: England |
Other Details:
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Languages: eng Pagination: 102-6 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Nijmegen, NL-6500 HB Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantigens
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chemistry,
immunology* Exoribonucleases / chemistry, immunology* Humans Multienzyme Complexes / chemistry, immunology* Polymyositis / enzymology*, immunology* Scleroderma, Systemic / enzymology*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantigens; 0/Multienzyme Complexes; 0/polymyosistis-scleroderma antigen, human; EC 3.1.-/Exoribonucleases |
| Comments/Corrections | |
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