| The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination. | |
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MedLine Citation:
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PMID: 20694010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strategies of herpesviruses, we initially identified two new cellular microRNAs that targeted MICB and were expressed differently both in healthy tissues and during melanocyte transformation. We show that coexpression of various pairs of cellular microRNAs interfered with the downregulation of MICB, whereas the viral microRNAs optimized their targeting ability to efficiently downregulate MICB. Moreover, we demonstrate that through site proximity and possibly inhibition of translation, a human cytomegalovirus (HCMV) microRNA acts synergistically with a cellular microRNA to suppress MICB expression during HCMV infection. |
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Authors:
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Daphna Nachmani; Dikla Lankry; Dana G Wolf; Ofer Mandelboim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-08 |
Journal Detail:
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Title: Nature immunology Volume: 11 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 806-13 Citation Subset: IM |
Affiliation:
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The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line, Tumor Cytomegalovirus / immunology* Down-Regulation Flow Cytometry Gene Expression Regulation Hela Cells Herpesvirus 4, Human Herpesvirus 8, Human Histocompatibility Antigens Class I / genetics, immunology Host-Pathogen Interactions Humans Immune Evasion* Killer Cells, Natural / immunology MicroRNAs / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class I; 0/MICB antigen; 0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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