| The human cytokine TSLP triggers a cell autonomous dendritic cell migration in confined environments. | |
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MedLine Citation:
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PMID: 21772055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dendritic cells (DCs) need to migrate in the interstitial environment of peripheral tissues to reach secondary lymphoid organs and initiate a suitable immune response. Whether and how inflamed tissues instruct DCs to emigrate is not fully understood. In this study, we report the unexpected finding that the epithelial-derived cytokine TSLP triggers chemokinesis of resting primary human DCs in a cell autonomous manner. TSLP induced the polarization of both microtubule and actin cytoskeletons and promoted DC three-dimensional migration in transwell as well as in microfabricated channels that mimic the confined environment of peripheral tissues. TSLP-induced migration relied on the actin-based motor myosin II and was inhibited by blebbistatin. Accordingly, TSLP triggered the re-distribution of phosphorylated myosin II regulatory light chain to the actin cortex, indicating that TSLP induces DC migration by promoting actomyosin contractility. Thus, TSLP produced by epithelial cells in inflamed tissue has a critical function in licensing DCs for cell-autonomous migration. This indicates that cytokines can directly trigger cell migration, which has important implications in immune physiopathology and vaccine design. |
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Authors:
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Maria-Isabel Fernandez; Mélina L Heuzé; Carolina Martinez-Cingolani; Elisabetta Volpe; Marie-Helene Donnadieu; Matthieu Piel; Bernhard Homey; Ana-Maria Lennon-Duménil; Vassili Soumelis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut National de la Sante et de la Recherche Medicale U932, Paris, France; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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