Document Detail

Is human chorionic gonadotropin directly involved in the regulation of human implantation?
MedLine Citation:
PMID:  17367920     Owner:  NLM     Status:  MEDLINE    
The regulation of human implantation is not fully understood. hCG as one of the earliest embryonal signals may be a major regulator in the parakrine embryo-endometrial communication. The expression of full-length hCG/LH-receptor mRNA could be demonstrated in human endometrium throughout the follicular and secretory phase of the menstrual cycle. In contrast, in early pregnancy decidua only truncated variants could be detected. To investigate direct effects of hCG on the human endometrium, an intrauterine microdialysis device was developed to measure parakrine mediators within the uterine cavity in vivo. Using this system, hCG was applied in the secretory phase and the endometrial response was evaluated. The administration of hCG (500 IU/ml) provoked a significant inhibition of intrauterine IGFBP-1 and M-CSF, while LIF, VEGF and MMP-9 were significantly stimulated. Taken together there appear to be multiple direct effects of hCG on the endometrium that precede the classical endocrine role of the hormone.
P Licht; H Fluhr; J Neuwinger; D Wallwiener; L Wildt
Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-14
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  269     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Fertility Center Nuremberg, Agnesgasse 2-4, 90403 Nuremberg, Germany.
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MeSH Terms
Cell Adhesion / physiology
Cell Communication / physiology
Chorionic Gonadotropin / pharmacology,  physiology*
Embryo Implantation / physiology*
Embryo, Mammalian / physiology
Endometrium / physiology
Fertility / drug effects
Models, Biological
Neovascularization, Physiologic
Receptors, LH / physiology
Trophoblasts / drug effects
Uterus / blood supply,  chemistry
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Receptors, LH

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