Document Detail


The human body may buffer small differences in meal size and timing during a 24-h wake period provided energy balance is maintained.
MedLine Citation:
PMID:  12949360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because approximately 20% of the work force in the industrialized world have irregular working hours, it is pertinent to study the consequences of eating at irregular, especially nighttime hours. We studied the postprandial responses during nocturnal fasting vs. eating throughout a 24-h wake period. Seven healthy males were studied twice in a crossover design. After a 6-d diet adjustment period [high fat diet, 45 energy percent (en%) fat, 40 en% carbohydrates)] with sleep from 2300 to 0700 h, the men were kept awake for 24 h at the metabolic ward and given either 6 isoenergetic meals, i.e., every 4 h (N-eat) or 4 isoenergetic meals from 0800 to 2000 h followed by a nocturnal fast (N-fast), with the same 24-h energy intake. Energy expenditure, substrate utilization, activity, heat release, body temperature and blood variables were measured over 24 h. Energy expenditure and blood glucose, triacylglycerol, insulin and glucagon concentrations were lower and nonesterified fatty acids concentrations were higher during the nocturnal fast than during nocturnal eating (P < 0.05); however, no 24-h differences between the protocols were apparent. Nocturnal fasting slightly altered the secretory patterns of the thyroid hormones and cortisol (P < 0.05). We found no clear indication that it would be more favorable to ingest few larger daytime meals than smaller meals throughout the 24-h period. The body seems to be able to buffer small differences in meal size and timing provided energy balance is maintained.
Authors:
Ulf Holmbäck; Arne Lowden; Torbjörn Akerfeldt; Maria Lennernäs; Leif Hambraeus; Jeanette Forslund; Torbjörn Akerstedt; Mats Stridsberg; Anders Forslund
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2003-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2748-55     Citation Subset:  IM    
Affiliation:
Department of Medical Sciences, Nutrition, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Ulf.Holmback@medsci.uu.se
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Adult
Blood Glucose / metabolism
Circadian Rhythm*
Cross-Over Studies
Eating / physiology
Energy Metabolism*
Fatty Acids, Nonesterified / blood
Feeding Behavior*
Glucagon / blood
Humans
Hydrocortisone / secretion
Insulin / blood
Male
Osmolar Concentration
Thyroid Hormones / secretion
Triglycerides / blood
Wakefulness*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Thyroid Hormones; 0/Triglycerides; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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