Document Detail


The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.
MedLine Citation:
PMID:  8648694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
p12I is a small hydrophobic protein encoded by the human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) that interacts with the 16-kDa component of the H+ vacuolar ATPase and cooperates with bovine papillomavirus 1 E5 oncoprotein in cell transformation. Just as an important step in E5 action appears to be its binding to the platelet-derived growth factor receptor, it was found that p12I binds specifically to both the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R). The IL-2R beta and gamma(c) chains associated with p12I are endoglycosidase-H sensitive, suggesting that their interaction occurs in a pre-Golgi compartment. p12I stabilizes the immature forms of the IL-2R beta and gamma(c) chains and decreases their cell surface expression. The interactions of p12I with IL-2R beta and gamma(c) may have important implications in the immunosuppressive effect of HTLV-1 in vivo as well as in the ligand-independent HTLV-1-mediated T-cell proliferation.
Authors:
J C Mulloy; R W Crownley; J Fullen; W J Leonard; G Franchini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  70     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-23     Completed Date:  1996-07-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3599-605     Citation Subset:  IM; X    
Affiliation:
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Golgi Apparatus / metabolism
HTLV-I Infections / immunology
Hela Cells
Human T-lymphotropic virus 1 / chemistry*
Humans
Receptors, Interleukin-2 / analysis,  metabolism*
Retroviridae Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Interleukin-2; 0/Retroviridae Proteins
Comments/Corrections

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