Document Detail

The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).
MedLine Citation:
PMID:  12527918     Owner:  NLM     Status:  MEDLINE    
The MLL gene at chromosome 11q23 is frequently rearranged in acute leukemia. Here we report the identification of a new MLL fusion partner in the case of an infant with AML-M4 and a t(11;17)(q23;q21) translocation. Fluorescence in situ hybridization (FISH) and RT-PCR analyses indicated a rearrangement of the MLL gene, but no fusion with previously identified MLL fusion partners at 17q, such as AF17 or MSF. Rapid amplification of cDNA ends (RACE) revealed an in-frame fusion of MLL to LASP1, a gene that is amplified and overexpressed in breast cancer. Retroviral transduction of myeloid progenitors demonstrated that MLL/LASP1 is the fourth known fusion of MLL with a cytoplasmic protein that has no in vitro transformation capability, thus establishing a potential subgroup among the MLL fusion proteins.
Sabine Strehl; Arndt Borkhardt; Robert Slany; Uta E Fuchs; Margit König; Oskar A Haas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  22     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
CCRI, Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria.
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MeSH Terms
Acute Disease
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 17*
Cytoskeletal Proteins
DNA-Binding Proteins / genetics*
Homeodomain Proteins / genetics*
In Situ Hybridization
Leukemia, Myeloid / genetics*
Molecular Sequence Data
Myeloid-Lymphoid Leukemia Protein
Neoplasm Proteins*
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors*
Translocation, Genetic*
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Cytoskeletal Proteins; 0/DNA-Binding Proteins; 0/Homeodomain Proteins; 0/LASP1 protein, human; 0/MLL protein, human; 0/Neoplasm Proteins; 0/Transcription Factors; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

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