Document Detail


The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.
MedLine Citation:
PMID:  3211147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously described the isolation of a human oncogene which had acquired transforming potential by a DNA rearrangement accompanying transfection of NIH 3T3 cells with human tumor DNA (X. Zhan, A. Culpepper, M. Reddy, J. Loveless, and M. Goldfarb, Oncogene 1:369-376, 1987). We now term this oncogene the FGF-5 gene, since it specifies the fifth documented protein related to fibroblast growth factors (FGFs. Two regions of the FGF-5 sequence, containing 122 of its 267 amino acid residues, were 40 to 50% homologous to the sequences of acidic and basic FGFs as well as to the sequences of the FGF-related oncoproteins int-2 and hst/KS3. The FGF-5 gene bears the three exon structures typical for members of this family. FGF-5 was found to be expressed in the neonatal brain and in 3 of the 13 human tumor cell lines examined. Several experiments strongly suggested that FGF-5 is a growth factor with properties common to those of acidic and basic FGFs. The rearrangement which activated the FGF-5 gene during DNA transfection had juxtaposed a retrovirus transcriptional enhancer just upstream from the native promoter of the gene.
Authors:
X Zhan; B Bates; X G Hu; M Goldfarb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  8     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-02-23     Completed Date:  1989-02-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3487-95     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M21617;  M23534;  M23535;  M23536
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
Fibroblast Growth Factors / genetics*,  isolation & purification
Genes*
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Molecular Sequence Data
Neoplasm Proteins / genetics*
Oncogenes*
Recombinant Fusion Proteins / isolation & purification
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Recombinant Fusion Proteins; 62031-54-3/Fibroblast Growth Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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