| hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae. | |
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MedLine Citation:
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PMID: 1639478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy. |
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Authors:
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Y Mistry; D B Young; R Mukherjee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Infection and immunity Volume: 60 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-08-28 Completed Date: 1992-08-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3105-10 Citation Subset: IM |
Affiliation:
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Microbiology Division, National Institute of Immunology, Shahid Jeet Singh Marg, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Heat-Shock Proteins / biosynthesis* Hot Temperature* Leprosy / immunology, metabolism* Macaca mulatta Mice Mice, Inbred BALB C Phagocytosis Schwann Cells / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins |
| Comments/Corrections | |
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