Document Detail


hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.
MedLine Citation:
PMID:  1639478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.
Authors:
Y Mistry; D B Young; R Mukherjee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  60     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3105-10     Citation Subset:  IM    
Affiliation:
Microbiology Division, National Institute of Immunology, Shahid Jeet Singh Marg, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Heat-Shock Proteins / biosynthesis*
Hot Temperature*
Leprosy / immunology,  metabolism*
Macaca mulatta
Mice
Mice, Inbred BALB C
Phagocytosis
Schwann Cells / metabolism*
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins
Comments/Corrections

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