Document Detail


The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system.
MedLine Citation:
PMID:  22537498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells perform wide varieties of functions that are facilitated, in part, by adopting unique shapes. Many of the genes and pathways that promote cell fate specification have been elucidated. However, relatively few transcription factors have been identified that promote shape acquisition after fate specification. Here we show that the Nkx5/HMX homeodomain protein MLS-2 is required for cellular elongation and shape maintenance of two tubular epithelial cells in the C. elegans excretory system, the duct and pore cells. The Nkx5/HMX family is highly conserved from sea urchins to humans, with known roles in neuronal and glial development. MLS-2 is expressed in the duct and pore, and defects in mls-2 mutants first arise when the duct and pore normally adopt unique shapes. MLS-2 cooperates with the EGF-Ras-ERK pathway to turn on the LIN-48/Ovo transcription factor in the duct cell during morphogenesis. These results reveal a novel interaction between the Nkx5/HMX family and the EGF-Ras pathway and implicate a transcription factor, MLS-2, as a regulator of cell shape.
Authors:
Ishmail Abdus-Saboor; Craig E Stone; John I Murray; Meera V Sundaram
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-17
Journal Detail:
Title:  Developmental biology     Volume:  366     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2013-07-05     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-307     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology,  embryology,  physiology*
Caenorhabditis elegans Proteins / physiology*
Cell Differentiation
Cell Shape*
Epithelial Cells / cytology*,  physiology
Gene Expression Regulation, Developmental
Homeodomain Proteins / physiology*
Morphogenesis
Signal Transduction
Transcription Factors / physiology
Grant Support
ID/Acronym/Agency:
GM083145/GM/NIGMS NIH HHS; GM58540/GM/NIGMS NIH HHS; R01 GM058540/GM/NIGMS NIH HHS; R01 GM058540-09/GM/NIGMS NIH HHS; T32 GM008216/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Homeodomain Proteins; 0/Lin-48 protein, C elegans; 0/MLS-2 protein, C elegans; 0/Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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