| A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins. | |
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MedLine Citation:
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PMID: 20706281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To reach the central nervous system (CNS), pathogens have to circumvent the wall of tightly sealed endothelial cells that compose the blood-brain barrier. Neuronal projections that connect to peripheral cells and organs are the Achilles heels in CNS isolation. Some viruses and bacterial toxins interact with membrane receptors that are present at nerve terminals to enter the axoplasm. Pathogens can then be mistaken for cargo and recruit trafficking components, allowing them to undergo long-range axonal transport to neuronal cell bodies. In this Review, we highlight the strategies used by pathogens to exploit axonal transport during CNS invasion. |
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Authors:
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Sara Salinas; Giampietro Schiavo; Eric J Kremer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Microbiology Volume: 8 ISSN: 1740-1534 ISO Abbreviation: Nat. Rev. Microbiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101190261 Medline TA: Nat Rev Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 645-55 Citation Subset: IM |
Affiliation:
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Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 34293 Montpellier Cedex 5, France. sara.salinas@igmm.cnrs.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Axonal Transport Bacterial Physiological Phenomena* Bacterial Toxins / metabolism* Blood-Brain Barrier Nervous System / microbiology*, virology* Virus Physiological Phenomena* |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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