Document Detail

The hitchhikers guide to cancer stem cell theory: Markers, pathways and therapy.
MedLine Citation:
PMID:  22997049     Owner:  NLM     Status:  Publisher    
Cancer stem cell (CSC) biology is a rapidly developing field within cancer research. CSCs are postulated to be a unique cell population exclusively capable of infinite self renewal, multilineage differentiation and with ability to evade conventional cytotoxic cancer therapy. These traits distinguish CSCs from their more differentiated counterparts, which possess only limited or no potential for self renewal and tumor initiation. Therefore, CSCs would be the driving motor of malignant growth and therapy resistance. Accordingly, successful cancer treatment would need to eliminate this highly potent group of cells, since even small residual numbers would suffice to recapitulate the disease after therapy. Putative CSCs has been identified in a broad range of human malignancies and several cell surface markers have been associated with their stem cell phenotype. Despite all efforts, a pure CSC population has not been isolated and often in vitro clonogenic and in vivo tumorigenic potential is found in several cell populations with occasionally contradictory surface marker signatures. Here, we give a brief overview of recent advances in CSC theory, including the signaling pathways in CSCs that also appear crucial for stem cells homeostasis in normal tissues. We discuss evidence for the interaction of CSCs with the stromal tumor environment. Finally, we review the emerging potentially effective CSC-targeted treatment strategies and their future role in therapy. © 2012 International Society for Advancement of Cytometry.
Akos Fábián; György Vereb; János Szöllősi
Related Documents :
24286309 - Selenite induces apoptosis in colorectal cancer cells through interaction with thioredo...
24810239 - Synthesis, characterization and mechanistic-insight into the anti-proliferative potenti...
24849329 - Use of metformin alone is not associated with survival outcomes of colorectal cancer ce...
23788939 - Evaluation of serum levels of scd30l ligand in patients with ovarian cancer in terms of...
18057009 - Nuclear survivin has reduced stability and is not cytoprotective.
21396839 - Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of ger...
24178709 - Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
11906749 - Novel miniaturized systems in high-throughput screening.
24812569 - Proapoptotic and antiproliferative effects of thymus caramanicus on human breast cancer...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  Cytometry. Part A : the journal of the International Society for Analytical Cytology     Volume:  -     ISSN:  1552-4930     ISO Abbreviation:  Cytometry A     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235694     Medline TA:  Cytometry A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Society for Advancement of Cytometry.
Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Students Aggress Against Professors in Reaction to Receiving Poor Grades: An Effect Moderated by Stu...
Next Document:  An approach for calculating a confidence interval from a single aquatic sample for monitoring hydrop...