Document Detail

The history of controlled hypotension.
MedLine Citation:
PMID:  240370     Owner:  NLM     Status:  MEDLINE    
As the physiology of deliberate hypotension has been unravelled, and as each new pharmacological agent has become available which either depresses or blocks peripheral vascular tone, depresses myocardial performance, or interferes with the conducting tissues within the myocardium, its possible incorporation into the armamentarium of the anaesthetist who offers induced hypotension has been considered. The result has been a sequence of variations in technique of characteristically recognizable vintage. No matter how the condition of induced hypotension is produced, there is usually vasodilatation, and the characteristic disturbance in physiology is of a loss of postural reactivity in the cardiovascular system. Important lessons have been learned concerning the management of shock states. Though it is difficult to evaluate the morbidity of deliberate induced hypotension, and terms such as "physiological trespass" have been used by its antagonists, it would appear that a well-considered and skilfully managed controlled hypotension is no more of a physiological trespass than anaesthesia, nor indeed than the trespass of the surgeon's knife itself.
J M Leigh
Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-12-12     Completed Date:  1975-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  745-9     Citation Subset:  IM; Q    
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MeSH Terms
Anesthesia / history
Ganglionic Blockers / therapeutic use
History, 19th Century
History, 20th Century
Hypotension, Controlled / history*,  mortality
Neuromuscular Blocking Agents
Respiration, Artificial / history
Shock / therapy
Reg. No./Substance:
0/Ganglionic Blockers; 0/Neuromuscular Blocking Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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