Document Detail

A history of alternative reinforcement reduces stimulus generalization of ethanol-seeking in a rat recovery model.
MedLine Citation:
PMID:  23122598     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Longer periods of recovery reduce the likelihood of relapse, which may be due to a reduced ability of various stimuli to occasion alcohol or drug seeking. However, this hypothesis remains largely uninvestigated.
METHODS: Here we assessed the ability of intermediate stimuli to occasion responding for ethanol in rats trained to discriminate an 8 kHz tone signaling a food fixed-ratio (FR) of 5 and an ethanol FR5, from a 16 kHz tone signaling a food FR150 and ethanol FR5. In the presence of the 8 kHz tone responding for food predominates, and in the presence of the 16 kHz tone, responding for ethanol predominates.
RESULTS: In the context of alternation between these conditions, varying the tone from 8 to 16 kHz produces a graded increase in ethanol (versus food) responding, consistent with a stimulus generalization function. A recent history of responding under food-predominant choice conditions, either during the test session or in the four sessions that precede it shifts the generalization function downwards. Extending this history to nine sessions shifts the curve further downwards. The stimulus generalization function was similar in a separate group, trained with different relative ratios for food and ethanol, but with similar behavioral allocation under each discriminative stimulus. Finally, withholding access to food and ethanol for 4 or 16 sessions did not affect the stimulus generalization gradient.
CONCLUSION: These results suggest that longer histories of reinforced alternative behavior might reduce the likelihood of relapse by decreasing the control exerted over alcohol- or drug-seeking by stimuli similar to those that previously occasioned alcohol- or drug-seeking.
Brett C Ginsburg; R J Lamb
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-31
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  129     ISSN:  1879-0046     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-12     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  94-101     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Acoustic Stimulation
Alcoholism / psychology*,  rehabilitation
Central Nervous System Depressants / pharmacology
Choice Behavior
Conditioning, Operant
Data Interpretation, Statistical
Drug-Seeking Behavior / physiology*
Ethanol / pharmacology
Generalization (Psychology) / physiology*
Rats, Inbred Lew
Reinforcement (Psychology)*
Reinforcement Schedule
Grant Support
Reg. No./Substance:
0/Central Nervous System Depressants; 3K9958V90M/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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