| A historical view from thirty eventful years of immunotherapy in autoimmune diabetes. | |
| | |
MedLine Citation:
|
PMID: 21846589 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Type 1 diabetes is an autoimmune disease. It was thus logical to attempt preventing or stopping the progression of the disease by immunotherapy. Following the strategies used in organ transplantation, the first trials in the 80s used cyclosporin in patients presenting recently diagnosed Type 1 diabetes. The effect was spectacular but waned when the treatment was stopped as the effect was non antigen-specific. Going back from bed to bench-side major efforts were then devoted to device strategies allowing induction or restoration of self-tolerance. Two major approaches provided encouraging results when used in spontaneous models of autoimmune diabetes that are the use of β-cell autoantigens and of monoclonal antibodies to CD3. Based on these results academic phase II trials and subsequently pharmaceutically driven phase III trials were launched. Results are now available and when critically analyzed in the frame of these last three decades they provide support to the possibility of making step by step immunotherapy available to all new onset diabetic patients with a hope of inducing long-term remission of the disease if the treatment is started sufficiently early, immediately after diagnosis. |
| | |
Authors:
|
Jean-François Bach; Lucienne Chatenoud |
Related Documents
:
|
102099 - The value of continuous ecg monitoring during treatment of diabetic ketoacidosis. a com... 1591899 - Persistent hyperkalemia in a patient with diabetes mellitus: a reversible defect in kal... 12679319 - A new agent, blue and radioactive, for sentinel node detection. 22246849 - Insulin sensitivity modifies the relationship between thyroid function and lipid profil... 15132889 - Diabetes in african americans: unique pathophysiologic features. 8153679 - Diabetic ketoacidosis--a study of 33 episodes. 15871859 - Plasma homocysteine levels in patients with type 2 diabetes in a mediterranean populati... 8240659 - Coxsackievirus b4 alters pancreatic glutamate decarboxylase expression in mice soon aft... 15114469 - Temporal changes in prevalence of diabetes and impaired glucose tolerance associated wi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-14 |
Journal Detail:
|
Title: Seminars in immunology Volume: - ISSN: 1096-3618 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
Université Paris Descartes, 75015 Paris, France; INSERM, Unité 1013, 75015 Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does preoperative anxiety and depression predict satisfaction after total knee replacement?
Next Document: Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.