Document Detail

A historical perspective and review of the safety of lipid emulsion in pregnancy.
MedLine Citation:
PMID:  1775114     Owner:  NLM     Status:  MEDLINE    
Total parenteral nutrition for pregnant patients is essential to maintain or restore optimal nutritional status for both the mother and fetus when adequate protein and caloric intake by the oral or enteral route is not feasible. This report reviews the safety of intravenous lipid emulsions in total parenteral nutrition programs for pregnant patients. Controversy regarding the adverse effects of intravenous lipid emulsion when administered to pregnant patients is based on early reports of the use of cottonseed oil lipid emulsions. The adverse effects reported included infarction of the placenta, ketonemia, increased myometrial activity, and induction of labor. In 32 subsequent case reports in which soybean oil- or soybean/safflower oil-based emulsions were used in total parenteral nutrition programs for pregnant patients, there was no relationship apparent between onset of labor and harmful maternal or fetal effects associated with the administration of lipid emulsion. It appears that the currently available soybean and soybean/safflower lipid-based emulsions can be safely administered to pregnant patients.
P Amato; R A Quercia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition     Volume:  6     ISSN:  0884-5336     ISO Abbreviation:  Nutr Clin Pract     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-03-05     Completed Date:  1992-03-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8606733     Medline TA:  Nutr Clin Pract     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  N    
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MeSH Terms
Fat Emulsions, Intravenous / adverse effects*,  standards
Nutrition Disorders / therapy*
Pregnancy Complications / therapy*
Reg. No./Substance:
0/Fat Emulsions, Intravenous

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