Document Detail

A historical perspective of aromatase inhibitors for ovulation induction.
MedLine Citation:
PMID:  23200665     Owner:  NLM     Status:  In-Data-Review    
The concept of using aromatase inhibitors in place of clomiphene citrate (CC) for ovulation induction was introduced >10 years ago; a brief history of its development is presented. Its worldwide usage for ovulation induction, including as an adjunct for intrauterine insemination and in vitro fertilization has occurred despite the absence of definitive data of superiority to CC. The results of two ongoing potentially definitive multicenter trials of efficacy and safety of letrozole compared with CC are eagerly awaited.
Robert F Casper; Mohamed F M Mitwally
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1352-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Samuel Lunenfeld Research Institute, Departments of Physiology and Endocrinology, and Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada. Electronic address:
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