Document Detail


The historical basis of a misconception leading to undertreating atopic dermatitis (eczema): facts and controversies.
MedLine Citation:
PMID:  20082950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of atopic dermatitis.
Authors:
David Farhi; Alain Ta?eb; G?rard Tilles; Daniel Wallach
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in dermatology     Volume:  28     ISSN:  1879-1131     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Service de Dermatologie, Pavillon Tarnier, H?pital Cochin, Assistance Publique - H?pitaux de Paris, Facult? de M?decine, Universit? Ren? Descartes - Paris V, 75014 Paris, France. david.farhi@cch.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Anti-Infective Agents / therapeutic use
Clinical Trials as Topic
Complementary Therapies / methods
Dermatitis, Atopic / classification,  prevention & control,  therapy*
Dermatologic Agents / administration & dosage
Desensitization, Immunologic / methods
Diet Therapy / methods
Drugs, Chinese Herbal / therapeutic use
Eczema / classification,  prevention & control,  therapy*
Evidence-Based Medicine*
Health Knowledge, Attitudes, Practice*
Humans
Immunosuppressive Agents / therapeutic use
Research Design
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Infective Agents; 0/Dermatologic Agents; 0/Drugs, Chinese Herbal; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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