Document Detail

The histopathology of the spleen from a patient with lepromatous leprosy.
MedLine Citation:
PMID:  6969229     Owner:  NLM     Status:  MEDLINE    
The histopathology of the spleen from a young man with diffuse non-nodular lepromatous leprosy is reported. As judged by this case, other case reports, and necropsy series, involvement of the spleen in lepromatous leprosy is characterized by aggregations of large vacuolated histiocytes, containing individual bacilli and globi, in both the red and white pulp. In the white pulp the histiocytes localize about the arterioles. Findings in the present case, which may represent a comparatively early change, include numerous, small germinal centers containing nonaggregated large, vacuolated histiocytes with intracellular bacilli.
T H Rea; L Bevans; C R Taylor
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  48     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
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MeSH Terms
Histiocytes / pathology
Leprosy / immunology,  pathology*
Spleen / pathology*
T-Lymphocytes / pathology

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