Document Detail

A histopathological study of cutaneous leishmaniasis in Sri Lanka.
MedLine Citation:
PMID:  21341622     Owner:  NLM     Status:  In-Process    
OBJECTIVES: To classify skin lesions into histological groups, to assess parasitic load, density of each inflammatory cell type and necrosis and to characterise the lymphocytic reaction in cutaneous leishmaniasis in comparison to leprosy.
METHODS: Skin biopsies from 31 patients with demonstrable amastigotes in smears or tissue sections were studied. The lesions were classified by two independent observers into four distinct histological groups based on different cell types in the inflammatory infiltrate and formation of granulomata. Parasitic load and the presence of necrosis were recorded. Immunohistochemical staining for CD45RO and CD20 for counting T and B cells respectively was done.
RESULTS: Histological groups of cutaneous leishmaniasis ranging from group I-IV were similar to that of the spectrum in leprosy ranging from lepromatous to tuberculoid leprosy. The histological groups from I-IV showed a significant inverse relationship with the mean parasitic index. Necrosis was not a prominent feature. The mean percentage of T cells in the histological spectrum from group I-IV in leishmaniasis was similar to the spectrum from lepromatous to tuberculoid leprosy. Mean percentage of T cells were 20.1% in group I, 20.5% in group II, 33.8% in group III and 47.8% in group IV. Lepromatous, borderline tuberculoid and tuberculoid leprosy had 21.3%, 33.4% and 48.0% T cells respectively.
CONCLUSION: Cutaneous leishmaniasis is a spectral disease similar to leprosy. The mean percentage T cells from group I-IV were similar to those in the spectrum of leprosy and mean percentage B cells varied in a narrow range.
C H P Herath; N V I Ratnatunga; R Waduge; P Ratnayake; C N Ratnatunga; S Ramadasa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Ceylon medical journal     Volume:  55     ISSN:  0009-0875     ISO Abbreviation:  Ceylon Med J     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1264702     Medline TA:  Ceylon Med J     Country:  Sri Lanka    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Department of Pathology, Teaching Hospital, Peradeniya, Sri Lanka.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Degrees of accountability. Everyone's looking to gain an edge in the upcoming regs governing ACOs.
Next Document:  Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery...