| The histopathological and immunohistochemical characteristics of pigmentary and cystic glaucoma in the Golden Retriever. | |
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MedLine Citation:
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PMID: 19883466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A clinical syndrome comprising the formation of thin-walled cysts within the posterior chamber, proteinaceous exudation, and pigment dispersion, which typically culminates in glaucoma is recognized in the Golden Retriever breed. Although not uncommon, this syndrome has been relatively infrequently documented in the literature, particularly from a histological standpoint. Fifteen globes from Golden Retrievers presented to Eye Care for Animals between 2003 and 2009 were evaluated by routine hematoxylin and eosin (H&E) as well as immunohistochemical staining. Alcian blue, periodic acid Schiff (PAS), Masson's trichrome, Cytokeratin, Vimentin, Neuron Specific Enolase (NSE), S-100, and smooth muscle actin staining were performed. The thin-walled cysts stained positive with Vimentin, NSE, and S-100 in 15/15 globes, consistent with a ciliary body epithelial cellular origin. No globes demonstrated goniodysgenesis. All 15 globes exhibited free pigment within the trabecular meshwork. Little to no inflammatory infiltrate was noted in 15/15 eyes. These findings suggest that the term 'uveitis' may be an inappropriate description of this syndrome. |
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Authors:
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Douglas Esson; Micki Armour; Patricia Mundy; Charles S Schobert; Richard R Dubielzig |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary ophthalmology Volume: 12 ISSN: 1463-5224 ISO Abbreviation: Vet Ophthalmol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887377 Medline TA: Vet Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 361-8 Citation Subset: IM |
Affiliation:
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Eye Care for Animals, 3025 Edinger Ave, Tustin, CA 92780, USA. desson@eyecareforanimals.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dog Diseases / genetics, pathology* Dogs Genetic Predisposition to Disease* Glaucoma / genetics, pathology, veterinary* Glaucoma, Open-Angle / genetics, pathology, veterinary* Immunohistochemistry* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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