Document Detail

p300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala.
MedLine Citation:
PMID:  23328899     Owner:  NLM     Status:  MEDLINE    
Modifications in chromatin structure have been widely implicated in memory and cognition, most notably using hippocampal-dependent memory paradigms including object recognition, spatial memory, and contextual fear memory. Relatively little is known, however, about the role of chromatin-modifying enzymes in amygdala-dependent memory formation. Here, we use a combination of biochemical, behavioral, and neurophysiological methods to systematically examine the role of p300/CBP histone acetyltransferase (HAT) activity in the consolidation and reconsolidation of auditory Pavlovian fear memories. We show that local infusions of c646, a selective pharmacological inhibitor of p300/CBP activity, shortly following either fear conditioning or fear memory retrieval impair training and retrieval-related regulation of histone acetylation in the lateral nucleus of the amygdala (LA). Furthermore, we show that intra-LA infusion of c646 significantly impairs fear memory consolidation, reconsolidation, and associated neural plasticity in the LA. Our findings collectively suggest that p300/CBP HAT activity is critical for the consolidation and reconsolidation of amygdala-dependent Pavlovian fear memories.
Stephanie A Maddox; Casey S Watts; Glenn E Schafe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Learning & memory (Cold Spring Harbor, N.Y.)     Volume:  20     ISSN:  1549-5485     ISO Abbreviation:  Learn. Mem.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-07-01     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9435678     Medline TA:  Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-19     Citation Subset:  IM    
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MeSH Terms
Acetylation / drug effects
Acoustic Stimulation
Amygdala / drug effects,  physiology*
Analysis of Variance
Conditioning, Classical / drug effects,  physiology*
Electrodes, Implanted
Enzyme Inhibitors / adverse effects,  pharmacology
Evoked Potentials, Auditory / drug effects,  physiology
Memory / drug effects,  physiology*
Memory Disorders / chemically induced
Rats, Sprague-Dawley
Time Factors
p300-CBP Transcription Factors / metabolism*
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; EC Transcription Factors; EC factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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