Document Detail

The histological effects of intracerebral injection or infusion of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridinium) in rat and mouse.
MedLine Citation:
PMID:  3263168     Owner:  NLM     Status:  MEDLINE    
Bilateral infusion of MPTP into the substantia nigra, ventral tegmental area or putamen of the rat brain provoked accumulation of leucocytes, but the periphery of nigral lesions showed no significant nerve cell loss. Tyrosine hydroxylase labelling of dopaminergic perikarya showed a normal staining pattern. In contrast, MPP+ was more destructive. After one day there was local degeneration of neuronal and glial elements. After one month there was tissue necrosis and central cavitation, but, like MPTP, there was no evidence of selective nigral cell loss. Striatal injection of MPP+ also failed to produce retrograde nigral damage. It is concluded that the toxicity of MPP+ applied directly to the dopamine system is a consequence of a severe non-selective necrotic lesion.
W R Gibb; B Costall; A M Domeney; M E Kelly; R J Naylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  461     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  IM    
National Hospital for Nervous Diseases, London, U.K.
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MeSH Terms
Injections, Intraventricular
Leukocytes / physiology*
Neurotoxins / pharmacology*
Putamen / drug effects*,  immunology,  pathology
Pyridines / toxicity*
Pyridinium Compounds / toxicity*
Substantia Nigra / drug effects*,  immunology,  pathology
Tegmentum Mesencephali / drug effects*,  immunology,  pathology
Reg. No./Substance:
0/Neurotoxins; 0/Pyridines; 0/Pyridinium Compounds; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 48134-75-4/1-Methyl-4-phenylpyridinium

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