| A histological analysis of granulomatous hepatitis. | |
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MedLine Citation:
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PMID: 5086225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study has been made of 33 cases of granulomatous hepatitis. Of these, 12 were eventually established as cases of sarcoidosis, nine as cases of tuberculosis, and four as examples of primary biliary cirrhosis. No clinical diagnosis was ever reached in six cases. Analysis of the histological features of these cases shows that the presence of caseation or of tubercle bacilli will only allow for the diagnosis of approximately 50% of cases of tuberculosis. Histological features which are suggestive of tuberculosis are a paucity of granulomata, a scantiness of giant cells, a relatively mild surrounding chronic inflammatory cell infiltrate, and an absence of reticulin. The granulomata are more likely to be due to sarcoidosis if they are numerous, contain many giant cells, are confined to the portal areas, and show a well marked surrounding non-specific chronic inflammatory cell infiltrate. Histological features of cases in which no clinical diagnosis was reached suggest that they are more likely to be due to sarcoidosis than to tuberculosis. |
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Authors:
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M Hughes; H Fox |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 25 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1972 Sep |
Date Detail:
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Created Date: 1973-01-16 Completed Date: 1973-01-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 817-20 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Granuloma / diagnosis, pathology* Hepatitis / diagnosis, pathology* Humans Liver Cirrhosis, Biliary / diagnosis, pathology Sarcoidosis / diagnosis, pathology Tuberculosis / diagnosis, pathology |
| Comments/Corrections | |
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