Document Detail

A histological analysis of granulomatous hepatitis.
MedLine Citation:
PMID:  5086225     Owner:  NLM     Status:  MEDLINE    
A study has been made of 33 cases of granulomatous hepatitis. Of these, 12 were eventually established as cases of sarcoidosis, nine as cases of tuberculosis, and four as examples of primary biliary cirrhosis. No clinical diagnosis was ever reached in six cases. Analysis of the histological features of these cases shows that the presence of caseation or of tubercle bacilli will only allow for the diagnosis of approximately 50% of cases of tuberculosis. Histological features which are suggestive of tuberculosis are a paucity of granulomata, a scantiness of giant cells, a relatively mild surrounding chronic inflammatory cell infiltrate, and an absence of reticulin. The granulomata are more likely to be due to sarcoidosis if they are numerous, contain many giant cells, are confined to the portal areas, and show a well marked surrounding non-specific chronic inflammatory cell infiltrate. Histological features of cases in which no clinical diagnosis was reached suggest that they are more likely to be due to sarcoidosis than to tuberculosis.
M Hughes; H Fox
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  25     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1972 Sep 
Date Detail:
Created Date:  1973-01-16     Completed Date:  1973-01-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  817-20     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Granuloma / diagnosis,  pathology*
Hepatitis / diagnosis,  pathology*
Liver Cirrhosis, Biliary / diagnosis,  pathology
Sarcoidosis / diagnosis,  pathology
Tuberculosis / diagnosis,  pathology

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