Document Detail

A histologic and histometric assessment of the influence of nicotine on alveolar bone loss in rats.
MedLine Citation:
PMID:  17335377     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cigarette smoking has long been recognized as a risk factor for periodontal disease. The aim of this study was to perform quantitative and qualitative analyses of bone loss in the furcation region of periodontally healthy rats after daily systemic administration of nicotine or saline solution. METHODS: Thirty adult male Wistar rats were assigned randomly to twice daily subcutaneous injections of saline solution (control, group C) or nicotine (group N). The animals were sacrificed at 37, 44, or 51 days after the first subcutaneous injection. The specimens were processed for serial histologic sections, and the area of bone loss in the furcation region of the second molar was analyzed histometrically. RESULTS: Greater bone loss was detected in group N compared to group C on day 37 (16.36 +/- 5.84 mm(2) and 7.24 +/- 2.66 mm(2)), day 44 (15.12 +/- 4.57 mm(2) and 7.76 +/- 1.35 mm(2)), and day 51 (18.80 +/- 3.71 mm(2) and 8.74 +/- 2.61 mm(2)), respectively (P <0.05). Extension of bone loss appeared greater in the furcation region of group N where a thinner trabeculae bone was found. After day 37, bone loss did not increase significantly. CONCLUSIONS: Daily systemic administration of nicotine resulted in significantly greater bone loss in the furcation region compared to saline solution. This indicated a close association between nicotine and periodontal morbidity in rats.
Alvaro Francisco Bosco; Samara Bonfante; Juliano Milanezi de Almeida; Danielle Shima Luize; Maria José Hitomi Nagata; Valdir Gouveia Garcia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of periodontology     Volume:  78     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  D; IM    
Department of Surgery and Integrated Clinic, Division of Periodontics, Dental School of Araçatuba, University of the State of São Paulo Júlio de Mesquita Filho, Araçatuba, SP, Brazil.
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MeSH Terms
Alveolar Bone Loss / chemically induced*
Analysis of Variance
Furcation Defects / chemically induced
Nicotine / toxicity*
Nicotinic Agonists / toxicity*
Random Allocation
Rats, Wistar
Smoking / adverse effects*
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine

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