| The histologic fetoplacental inflammatory response in fatal perinatal group B-streptococcus infection. | |
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MedLine Citation:
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PMID: 15141264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the rate of histologic fetoplacental inflammation in fetuses and newborns with fatal perinatal Group B-Streptococcus (GBS) infection. STUDY DESIGN: Autopsy files (1990 to 2002) were searched for fetuses and newborns with GBS-positive post-mortem blood and/or lung cultures. The rate of histological fetoplacental inflammation in preterm (< 36 weeks gestational age) and term (> or =36 weeks) fetuses/infants was compared using chi(2) test. RESULTS: GBS infection was diagnosed in 4.9% (61/1236) of perinatal autopsies and was considered the exclusive cause of death in 58 cases (16 to 41 weeks gestation, median: 26 weeks). A total of 43 fetuses/infants (74%) were preterm, 24 (41%) were male and 33 (57%) stillborn. The histologic fetoplacental inflammatory response was age-dependent for the following variables: acute chorioamnionitis (seen in 67% of preterm vs 33% of term fetuses/infants, p < 0.05), multiple-vessel umbilical vasculitis (37 vs 7%, p < 0.05), funisitis (37 vs 13%, p < 0.05), and the presence of neutrophils in the gastrointestinal tract (35% vs none, p < 0.05). Neutrophils in the pulmonary airspaces (47 vs 33%) and pneumonia (16 vs 27%) were found with similar frequency in both groups. CONCLUSION: Histologic fetoplacental inflammation is a poor indicator of perinatal GBS infection; the sensitivity is 67% in preterm and 33% in term fetuses/newborns (overall sensitivity 59%). The higher rate of histologic inflammation in preterm fetuses/newborns suggests age-specific interactions between microorganism, host and placenta. |
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Authors:
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Monique E De Paepe; Rebecca M Friedman; Fusun Gundogan; Halit Pinar; Calvin E Oyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 24 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-29 Completed Date: 2004-10-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 441-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Women and Infants Hospital and Brown Medical School, 101 Dudley Street, Providence, RI 02905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorioamnionitis
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pathology Female Fetal Diseases / pathology* Gestational Age Humans Infant, Newborn Placenta / pathology* Pregnancy Retrospective Studies Sensitivity and Specificity Streptococcal Infections / mortality, pathology* Streptococcus agalactiae* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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