Document Detail

The histaminergic tuberomammillary nucleus is critical for motivated arousal.
MedLine Citation:
PMID:  20529118     Owner:  NLM     Status:  MEDLINE    
Obtaining food, shelter or water, or finding a mating partner are examples of motivated behaviors, which are essential to preserve the species. The full expression of such behaviors requires a high but optimal arousal state. We tested the idea that tuberomammillary nucleus (TMN) histamine neurons are crucial to generate such motivated arousal, using a model of the appetitive phase of feeding behavior. Hungry rats enticed with food within a wire mesh box showed intense goal-directed motor activity aimed at opening the box, an increase in core temperature, a fast histamine release in the hypothalamus and an early increase in Fos immunoreactivity in TMN and cortical neurons. Enticing with stronger-tasting food induced stronger motor, temperature and Fos immunoreactivity brain responses than ordinary food pellets. TMN lesion greatly decreased all of those responses. We conclude that histamine neurons increase arousal and vegetative activity, allowing the normal unfolding of voluntary, goal-directed behavior such as obtaining food.
José Luis Valdés; Cristián Sánchez; María Eugenia Riveros; Patrizio Blandina; Marco Contreras; Paula Farías; Fernando Torrealba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-01
Journal Detail:
Title:  The European journal of neuroscience     Volume:  31     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2073-85     Citation Subset:  IM    
Departamento de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
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MeSH Terms
Arousal / physiology*
Behavior, Animal / physiology*
Body Temperature
Feeding Behavior / physiology
Histamine / metabolism*
Hypothalamic Area, Lateral / cytology,  metabolism*,  pathology
Motor Activity / physiology
Neurons / cytology,  metabolism
Proto-Oncogene Proteins c-fos / metabolism
Rats, Sprague-Dawley
Stress, Psychological
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 51-45-6/Histamine

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