| The histamine H1 receptor is not involved in local control of mammary blood flow in dairy cows. | |
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MedLine Citation:
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PMID: 18487669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low concentrations of the essential amino acid histidine in circulation have been shown to increase mammary blood flow and it has been suggested that this effect is mediated by histamine. The hypotheses tested in this experiment were that interstitial histamine concentrations in the mammary gland are related to arterial His concentrations and that mammary blood flow is reduced by extracellular histamine via H(1) receptors. The hypotheses were tested by infusing saline or chlorpheniramine, a blocker of the H(1) histamine receptor, into the arterial supply of the mammary glands of lactating cows infused with 44 g/h of amino acid mixtures with or without His for 10 h. Infusates were administered in a 2 x 2 factorial arrangement within a 4 x 4 Latin square to 4 multiparous Holstein cows in mid lactation. Exclusion of His from the infusate decreased protein content in milk from the infused udder half from 3.98 to 3.77%, and increased arterial alpha-aminonitrogen concentration from 3.2 to 3.4 mM. Neither the decreased arterial His concentration nor the H(1) blocker affected plasma flow to the infused udder half. We conclude that histamine is not involved in the regulation of mammary blood flow. The H(1) blocker decreased milk production in the infused udder half from 4.6 to 3.5 kg without affecting protein, fat, and lactose percentages, suggesting an inhibition of milk ejection. Cows on chlorpheniramine ate less feed during the infusion than saline-infused cows, which resulted in lower arterial concentrations and mammary uptakes of acetate. The efficiency of plasma triacylglycerol uptake across the mammary glands was decreased by chlorpheniramine but net uptake of long-chain fatty acids was not affected. The mechanism by which an amino acid deficiency influences mammary blood flow does not involve histamine signaling through the H(1) receptor and remains unidentified. |
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Authors:
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T G Madsen; D R Trout; S R L Cieslar; N G Purdie; M O Nielsen; J P Cant |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dairy science Volume: 91 ISSN: 1525-3198 ISO Abbreviation: J. Dairy Sci. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-07-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985126R Medline TA: J Dairy Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2461-8 Citation Subset: IM |
Affiliation:
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Department of Basic Animal and Veterinary Sciences, The Faculty of Life Sciences, Copenhagen University, DK-1870 Frederiksberg C, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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pharmacology Amino Acids / deficiency Animal Nutritional Physiological Phenomena Animals Cattle Chlorpheniramine / pharmacology Female Histamine / blood, metabolism* Histamine H1 Antagonists / pharmacology* Histidine / metabolism Mammary Glands, Animal / blood supply*, drug effects Milk / chemistry, secretion* Milk Ejection / drug effects Receptors, Histamine H1 / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Amino Acids; 0/Histamine H1 Antagonists; 0/Receptors, Histamine H1; 132-22-9/Chlorpheniramine; 51-45-6/Histamine; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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