Document Detail

The hippocampus and depression.
MedLine Citation:
PMID:  15177085     Owner:  NLM     Status:  MEDLINE    
The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies. In the past two decades, advances in neuroimaging techniques now allow the examination of subtle changes in both regional structure and function that are associated with the pathophysiology of depression. Many studies using 3-dimensional magnetic resonance imaging (MRI) volumetric measurement have reported decreases in hippocampal volume among depressed subjects compared with controls, whereas other studies have not found any volume loss. Differences among studies have been discussed. In some studies, the volume loss appears to have functional significance including an association with memory loss. Furthermore, we have found a trend towards loss of 5-HT(2A) receptors in the hippocampus using positron emission tomography (PET) to detect regional changes in [18F]altanserin binding. Functional imaging extends the sensitivity and specificity of structural imaging and will lead to a better understanding of affective disorders.
Y I Sheline; B L Mittler; M A Mintun
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  17 Suppl 3     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2004-06-04     Completed Date:  2004-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  300-5     Citation Subset:  IM    
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Alzheimer Disease / physiopathology
Depressive Disorder, Major / metabolism,  physiopathology*
Hemodynamics / drug effects
Hippocampus / metabolism,  physiopathology*
Hypothalamo-Hypophyseal System / anatomy & histology,  blood supply,  physiopathology
Magnetic Resonance Imaging
Pituitary-Adrenal System / anatomy & histology,  blood supply,  physiopathology
Serotonin / metabolism
Tomography, Emission-Computed
Grant Support
Reg. No./Substance:

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