Document Detail

A highly conserved pericentromeric domain in human and gorilla chromosomes.
MedLine Citation:
PMID:  20068296     Owner:  NLM     Status:  MEDLINE    
Significant similarity between human and gorilla genomes has been found in all chromosome arms, but not in centromeres, using whole-comparative genomic hybridization (W-CGH). In human chromosomes, centromeric regions, generally containing highly repetitive DNAs, are characterized by the presence of specific human DNA sequences and an absence of homology with gorilla DNA sequences. The only exception is the pericentromeric area of human chromosome 9, which, in addition to a large block of human DNA, also contains a region of homology with gorilla DNA sequences; the localization of these sequences coincides with that of human satellite III. Since highly repetitive DNAs are known for their high mutation frequency, we hypothesized that the chromosome 9 pericentromeric DNA conserved in human chromosomes and deriving from the gorilla genome may thus play some important functional role.
M Pita; J Gos?lvez; A Gos?lvez; M Nieddu; C L?pez-Fern?ndez; R Mezzanotte
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-06
Journal Detail:
Title:  Cytogenetic and genome research     Volume:  126     ISSN:  1424-859X     ISO Abbreviation:  Cytogenet. Genome Res.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142708     Medline TA:  Cytogenet Genome Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Unidad de Gen?tica, Departamento de Biolog?a, Universidad Aut?noma de Madrid, Madrid , Spain.
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MeSH Terms
Chromosomes, Human, Pair 9 / genetics*
Chromosomes, Mammalian / genetics*
Conserved Sequence
DNA, Satellite / genetics*
Gorilla gorilla
In Situ Hybridization, Fluorescence / methods*
Reg. No./Substance:
0/DNA, Satellite

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