Document Detail

A higher prevalence of abnormal regional cerebral blood flow in patients with syndrome X and abnormal myocardial perfusion.
MedLine Citation:
PMID:  12718477     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that syndrome X is a systemic vascular disorder, technetium-99m ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in 30 patients with syndrome X. These patients were separated into group 1, 20 patients with definite myocardial perfusion defects diagnosed by thallium-201 (Tl-201) myocardial perfusion SPECT; and group 2, 10 patients without any myocardial perfusion defects. Tc-99m ECD brain SPECT demonstrated hypoperfusion brain lesions in 95% (19/20) and 20% (2/10) of patients in groups 1 and 2, respectively. This difference in the cidence between the two groups was significant. In group 1 and 2 patients, parietal lobes were the most common hypoperfusion areas, while the cerebellum was the least common hypoperfusion area of the brain. Syndrome X is a systemic vascular disorder with a high incidence of hypoperfusion lesions of the brain based on the findings of Tc-99m ECD brain SPECT, and is usually coincident with myocardial defects based on the Tl-201 myocardial perfusion SPECT findings.
Pei-Ying Pai; Feng-Yuan Liu; Albert Kao; Cheng-Chieh Lin; Cheng-Chun Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  44     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-29     Completed Date:  2003-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
Division of Cardiology, China Medical College Hospital, Taichung, Taiwan.
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MeSH Terms
Brain / blood supply*,  radionuclide imaging*
Cerebrovascular Circulation
Cysteine / analogs & derivatives*,  diagnostic use
Heart / radionuclide imaging
Microvascular Angina / physiopathology*,  radionuclide imaging*
Middle Aged
Organotechnetium Compounds / diagnostic use
Radiopharmaceuticals / diagnostic use
Regional Blood Flow
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine

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