Document Detail

A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes.
MedLine Citation:
PMID:  20216558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVES: There is controversy over dietary protein's effects on cardiovascular disease risk factors in diabetic subjects. It is unclear whether observed effects are due to increased protein or reduced carbohydrate content of the consumed diets. The aim of this study was to compare the effects of two diets differing in protein to fat ratios on cardiovascular disease risk factors.
SUBJECTS/METHODS: A total of 17 obese (body mass index (BMI) ranging from 31 to 45 kg/m(2)) volunteers with type 2 diabetes (DM2), aged 46+/-3 years, consumed two diets, each for 4 weeks, with 3 weeks of washout period in a random, blind, crossover design. The diets were: (1) a high-protein low-fat diet (HP-LF, with 30% protein, 50% carbohydrates and 20% fat) and (2) a low-protein high-fat diet (LP-HF, with 15% protein, 50% carbohydrates and 35% fat). Their effects on fasting glycemic control, lipid levels and blood pressure, and on postprandial glucose and insulin responses after a standard test meal at the beginning and end of each dietary intervention were analyzed.
RESULTS: Both diets were equally effective in promoting weight loss and fat loss and in improving fasting glycemic control, total cholesterol and low-density lipoprotein (LDL) cholesterol, but the HP-LF diet decreased to a greater extent triglyceride (TG) levels (P=0.04) when compared with the LP-HF diet. HP-LF diet improved significantly both systolic and diastolic blood pressure when compared with the LP-HF diet (P<0.001 and P<0.001, respectively). No differences were observed in postprandial glucose and insulin responses.
CONCLUSIONS: A protein to fat ratio of 1.5 in diets significantly improves blood pressure and TG concentrations in obese individuals with DM2.
E Papakonstantinou; D Triantafillidou; D B Panagiotakos; A Koutsovasilis; M Saliaris; A Manolis; A Melidonis; A Zampelas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-03-10
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  595-602     Citation Subset:  IM    
Department of Dietetics and Nutrition Sciences, Harokopio University, Athens, Greece.
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MeSH Terms
Adipose Tissue / metabolism
Blood Pressure*
Caloric Restriction
Cholesterol / blood
Cholesterol, LDL / blood
Cross-Over Studies
Diabetes Mellitus, Type 2 / blood,  complications,  diet therapy*
Diet, Fat-Restricted*
Diet, Protein-Restricted
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage*
Glucose Intolerance / blood
Middle Aged
Obesity / blood,  complications,  diet therapy*
Single-Blind Method
Triglycerides / blood*
Weight Loss
Reg. No./Substance:
0/Cholesterol, LDL; 0/Dietary Fats; 0/Dietary Proteins; 0/Triglycerides; 57-88-5/Cholesterol

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