| A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma. | |
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MedLine Citation:
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PMID: 8318826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A rapid and simple high performance liquid chromatographic analytical method is described for the simultaneous determination of norfloxacin and furprofen in rat plasma. Following dichloromethane extraction, the solution was chromatographed in a Vydac anion exchange column using a mobile phase of 0.05 M phosphate buffer (pH = 7.0): acetonitrile (80:20, v/v) at a flow-rate of 1.8 mL/min. The drugs were detected by UV absorption at 278 nm. The total chromatographic analysis time was 10 min. The response was linear, 0.1-5.0 micrograms/mL for norfloxacin and 0.1-3.0 micrograms/mL for furprofen, respectively. This method is useful for pharmacokinetic studies of these compounds and will facilitate detailed investigations into the interactions between quinolones and furprofen. |
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Authors:
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G Carlucci; P Mazzeo; G Palumbo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical chromatography : BMC Volume: 7 ISSN: 0269-3879 ISO Abbreviation: Biomed. Chromatogr. Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-07-30 Completed Date: 1993-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610241 Medline TA: Biomed Chromatogr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 126-8 Citation Subset: IM |
Affiliation:
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Dipartimento di Chimica, Ingegneria Chimica e Materiali, Università dell'Aquila, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid / methods*, standards, statistics & numerical data Female Male Norfloxacin / blood* Phenylpropionates / blood* Quality Control Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Phenylpropionates; 66318-17-0/furprofen; 70458-96-7/Norfloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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