Document Detail

A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration.
MedLine Citation:
PMID:  19608872     Owner:  NLM     Status:  MEDLINE    
Age-related macular degeneration (AMD) is one of the leading cause of blindness among the elderly; however, current therapy options are limited. Epidemiological studies have shown that a diet that is high in omega-3 polyunsaturated (n-3) fatty acids can slow disease progression in patients with advanced AMD. In this study, we evaluated the effect of such a diet on the retinas of Ccl2(-/-)/Cx3cr1(-/-) mice, a model that develops AMD-like retinal lesions that include focal deep retinal lesions, abnormal retinal pigment epithelium, photoreceptor degeneration, and A2E accumulation. Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Some mice that were given high levels of n-3 fatty acids had lesion reversion. We found a shunted arachidonic acid metabolism that resulted in decreased pro-inflammatory derivatives (prostaglandin E(2) and leukotriene B(4)) and an increased anti-inflammatory derivative (prostaglandin D(2)). We also measured lower ocular TNF-alpha and IL-6 transcript levels in the mice fed a diet of high n-3 fatty acids. Our findings in these mice are in line with human studies of AMD risk reduction by long-chain n-3 fatty acids. This murine model provides a useful tool to evaluate therapies that might delay the development of AMD.
Jingsheng Tuo; Robert J Ross; Alexandra A Herzlich; Defen Shen; Xiaoyan Ding; Min Zhou; Steven L Coon; Nahed Hussein; Norman Salem; Chi-Chao Chan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2009-07-16
Journal Detail:
Title:  The American journal of pathology     Volume:  175     ISSN:  1525-2191     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-27     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  799-807     Citation Subset:  AIM; IM    
10/10N103, NIH/NEI, 10 Center Dr., Bethesda, MD 20892-1857, USA.
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MeSH Terms
Arachidonic Acid / metabolism
Chemokine CCL2 / genetics
Disease Models, Animal
Fatty Acids, Omega-3 / administration & dosage*
Interleukin-6 / genetics
Macular Degeneration / pathology,  prevention & control,  therapy*
Mice, Mutant Strains
Pyridinium Compounds / metabolism
Receptors, Chemokine / genetics
Retinal Pigment Epithelium / drug effects*,  metabolism,  pathology
Retinoids / metabolism
Transcription, Genetic
Tumor Necrosis Factor-alpha / genetics
Reg. No./Substance:
0/A2E compound; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Cx3cr1 protein, mouse; 0/Fatty Acids, Omega-3; 0/Interleukin-6; 0/Pyridinium Compounds; 0/Receptors, Chemokine; 0/Retinoids; 0/Tumor Necrosis Factor-alpha; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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