| A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. | |
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MedLine Citation:
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PMID: 19608872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related macular degeneration (AMD) is one of the leading cause of blindness among the elderly; however, current therapy options are limited. Epidemiological studies have shown that a diet that is high in omega-3 polyunsaturated (n-3) fatty acids can slow disease progression in patients with advanced AMD. In this study, we evaluated the effect of such a diet on the retinas of Ccl2(-/-)/Cx3cr1(-/-) mice, a model that develops AMD-like retinal lesions that include focal deep retinal lesions, abnormal retinal pigment epithelium, photoreceptor degeneration, and A2E accumulation. Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Some mice that were given high levels of n-3 fatty acids had lesion reversion. We found a shunted arachidonic acid metabolism that resulted in decreased pro-inflammatory derivatives (prostaglandin E(2) and leukotriene B(4)) and an increased anti-inflammatory derivative (prostaglandin D(2)). We also measured lower ocular TNF-alpha and IL-6 transcript levels in the mice fed a diet of high n-3 fatty acids. Our findings in these mice are in line with human studies of AMD risk reduction by long-chain n-3 fatty acids. This murine model provides a useful tool to evaluate therapies that might delay the development of AMD. |
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Authors:
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Jingsheng Tuo; Robert J Ross; Alexandra A Herzlich; Defen Shen; Xiaoyan Ding; Min Zhou; Steven L Coon; Nahed Hussein; Norman Salem; Chi-Chao Chan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2009-07-16 |
Journal Detail:
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Title: The American journal of pathology Volume: 175 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-10-27 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 799-807 Citation Subset: AIM; IM |
Affiliation:
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10/10N103, NIH/NEI, 10 Center Dr., Bethesda, MD 20892-1857, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / metabolism Chemokine CCL2 / genetics Diet Disease Models, Animal Fatty Acids, Omega-3 / administration & dosage* Interleukin-6 / genetics Macular Degeneration / pathology, prevention & control, therapy* Mice Mice, Mutant Strains Pyridinium Compounds / metabolism Receptors, Chemokine / genetics Retinal Pigment Epithelium / drug effects*, metabolism, pathology Retinoids / metabolism Transcription, Genetic Tumor Necrosis Factor-alpha / genetics |
| Chemical | |
Reg. No./Substance:
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0/A2E compound; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Cx3cr1 protein, mouse; 0/Fatty Acids, Omega-3; 0/Interleukin-6; 0/Pyridinium Compounds; 0/Receptors, Chemokine; 0/Retinoids; 0/Tumor Necrosis Factor-alpha; 506-32-1/Arachidonic Acid |
| Comments/Corrections | |
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