| The high mobility group A1 gene: transforming inflammatory signals into cancer? | |
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MedLine Citation:
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PMID: 20068164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, whereas blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer. |
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Authors:
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Linda M S Resar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-01-12 |
Journal Detail:
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Title: Cancer research Volume: 70 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-03-09 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 436-9 Citation Subset: IM |
Affiliation:
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The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2109., USA. lresar@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transformation, Neoplastic / genetics*, metabolism HMGA1a Protein / biosynthesis, genetics* Humans Inflammation / genetics, pathology Mice Neoplasms / genetics, pathology |
| Grant Support | |
ID/Acronym/Agency:
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P50 CA096888/CA/NCI NIH HHS; P50 CA096888-01/CA/NCI NIH HHS; R01 CA092339/CA/NCI NIH HHS; R01 CA092339-01A1/CA/NCI NIH HHS; R01 CA092339-02/CA/NCI NIH HHS; R01 CA092339-03/CA/NCI NIH HHS; R01 CA092339-04/CA/NCI NIH HHS; R03 CA139331/CA/NCI NIH HHS; R03 CA139331-01/CA/NCI NIH HHS; R03 CA139331-02/CA/NCI NIH HHS; R21 CA118343-01A1/CA/NCI NIH HHS; R21 CA118343-02/CA/NCI NIH HHS; R21 CA18343/CA/NCI NIH HHS; R29 CA076130-02/CA/NCI NIH HHS; R29 CA076130-03/CA/NCI NIH HHS; R29 CA076130-04/CA/NCI NIH HHS; R29 CA076130-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124544-67-8/HMGA1a Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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