| A high-legume low-glycemic index diet reduces fasting plasma leptin in middle-aged insulin-resistant and -sensitive men. | |
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MedLine Citation:
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PMID: 21206508 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fasting leptin and ghrelin levels were measured in 36 insulin-sensitive (IS) and 28 insulin-resistant (IR) men who consumed a legume-enriched low-glycemic index (LG) diet or healthy American (HA) diet in a randomly ordered cross-over feeding study consisting of two 4-week periods. Weight remained stable over the entire study. Fasting plasma leptin was significantly reduced from pre-study levels by both the LG (18.8%, P<0.001) and HA (16.1%, P<0.001) diets, whereas fasting ghrelin did not change. By subgroup analysis according to prestudy insulin status, leptin was reduced in IR subjects after both the LG (17.1%, P<0.01) and the HA (33.3%, P<0.001) diets, whereas IS subjects responded only after the LG diet (23.1%, P<0.01). Thus, a legume-rich LG index diet may be a beneficial strategy for reducing circulating leptin concentrations, even under conditions of weight maintenance.European Journal of Clinical Nutrition advance online publication, 5 January 2011; doi:10.1038/ejcn.2010.273. |
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Authors:
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Z Zhang; E Lanza; A C Ross; P S Albert; N H Colburn; M J Rovine; D Bagshaw; J S Ulbrecht; T J Hartman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-05 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: - ISSN: 1476-5640 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nutritional Sciences, Chandlee Laboratory, The Pennsylvania State University, University Park, PA, USA. |
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