Document Detail

A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts.
MedLine Citation:
PMID:  12163676     Owner:  NLM     Status:  MEDLINE    
Genistein, a soy isoflavone, has in vitro immunosuppressive properties. We investigated whether genistein or dietary soy protein containing isoflavones could influence the outcome of rat cardiac allografts. Lewis rats were fed a diet with protein from high isoflavone soy protein fraction (HIS), casein (CAS) or casein with isoflavones added (CI) starting 1 wk before heart transplants from Wistar Furth donors, and continuing throughout the study. HIS-fed rats had significantly prolonged time to rejection compared with CAS- and CI-fed recipients (10.8 +/- 2.62 vs. 7.18 +/- 0.75 and 7.22 +/- 0.44 d, P < 0.001). Intravenous genistein [20mg/(kg. d) for 14 d] significantly prolonged heart survival compared with controls and dissolvent-treated recipients (23.2 +/- 7.4 vs. 8.4 +/- 1.3 and 11.4+/3.6 d, P < 0.0005), and had an additive effect when given to heart recipients also receiving low dose cyclosporine for 7 d (30.8 +/- 2.3 vs. 23.4 +/- 2.4 d, P < 0.005). Concanavalin A-stimulated lymphocytes, isolated from Lewis rats given intraperitoneal genistein for 7 d, had decreased production of interferon gamma compared with controls or dimethyl sulfoxide-treated groups (22.6 +/- 9.9 vs 149 +/- 105 and 154 +/- 103 micro g/L, P < 0.05). In conclusion, a high isoflavone soy diet and intravenous genistein, but not isoflavone extract alone, delay rejection of rat cardiac allografts, with an additive effect in cyclosporine-treated rats. In addition, intraperitoneal genistein has immunosuppressive properties in vivo.
Timothy P O'Connor; Daniel A Liesen; Paul C Mann; Lori Rolando; William J Banz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  132     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-06     Completed Date:  2002-09-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2283-7     Citation Subset:  IM    
Department of Surgery, Southern Illinois University School of Medicine, Springfield 62702, USA.
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MeSH Terms
Dietary Proteins / pharmacology*
Enzyme Inhibitors / administration & dosage,  therapeutic use
Genistein / administration & dosage,  therapeutic use*
Graft Rejection / prevention & control*
Graft Survival / drug effects,  physiology*
Heart Transplantation / immunology*
Injections, Intravenous
Isoflavones / pharmacology*
Rats, Inbred Lew
Rats, Inbred WF
Soybean Proteins*
Transplantation, Homologous / immunology
Reg. No./Substance:
0/Dietary Proteins; 0/Enzyme Inhibitors; 0/Isoflavones; 0/Soybean Proteins; 446-72-0/Genistein

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