| A high-fructose diet worsens eccentric left ventricular hypertrophy in experimental volume overload. | |
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MedLine Citation:
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PMID: 20971767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of left ventricular (LV) hypertrophy (LVH) can be affected by diet manipulation. Concentric LVH resulting from pressure overload can be worsened by feeding rats with a high-fructose diet. Eccentric LVH is a different type of hypertrophy and is associated with volume overload (VO) diseases. The impact of an abnormal diet on the development of eccentric LVH and on ventricular function in chronic VO is unknown. This study therefore examined the effects of a fructose-rich diet on LV eccentric hypertrophy, ventricular function, and myocardial metabolic enzymes in rats with chronic VO caused by severe aortic valve regurgitation (AR). Wistar rats were divided in four groups: sham-operated on control diet (SC; n = 13) or fructose-rich diet (SF; n = 13) and severe aortic regurgitation fed with the same diets [aortic regurgitation on control diet (ARC), n = 16, and aortic regurgitation on fructose-rich diet (ARF), n = 13]. Fructose-rich diet was started 1 wk before surgery, and the animals were euthanized 9 wk later. SF and ARF had high circulating triglycerides. ARC and ARF developed significant LV eccentric hypertrophy after 8 wk as expected. However, ARF developed more LVH than ARC. LV ejection fraction was slightly lower in the ARF compared with ARC. The increased LVH and decreased ejection fraction could not be explained by differences in hemodynamic load. SF, ARC, and ARF had lower phosphorylation levels of the AMP kinase compared with SC. A fructose-rich diet worsened LV eccentric hypertrophy and decreased LV function in a model of chronic VO caused by AR in rats. Normal animals fed the same diet did not develop these abnormalities. Hypertriglyceridemia may play a central role in this phenomenon as well as AMP kinase activity. |
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Authors:
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Andrée-Anne Bouchard-Thomassin; Dominic Lachance; Marie-Claude Drolet; Jacques Couet; Marie Arsenault |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-22 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H125-34 Citation Subset: IM |
Affiliation:
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Groupe de Recherche en Valvulopathies, Centre de Recherche, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Aortic Valve Insufficiency / metabolism, physiopathology Blotting, Western Dietary Carbohydrates / adverse effects*, metabolism Fructose / administration & dosage*, metabolism Hypertrophy, Left Ventricular / etiology*, metabolism, physiopathology* Male Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Stroke Volume Triglycerides / blood Ventricular Function, Left / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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MOP-61818//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Triglycerides; 30237-26-4/Fructose |
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