| A high-fat diet and the threonine-encoding allele (Thr54) polymorphism of fatty acid-binding protein 2 reduce plasma triglyceride-rich lipoproteins. | |
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MedLine Citation:
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PMID: 21840466 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The threonine-encoding allele (Thr54) of the fatty acid-binding protein 2 (FABP2) DNA polymorphism is associated with increased triglyceride (TG)-rich lipoproteins (TRL). We hypothesized that the TRL response to diets of varied fat content is affected by the FABP2 A54T polymorphism, specifically that a high-fat diet would reduce TRL and that the Thr54 allele would have an enhanced response. Sixteen healthy, postmenopausal women completed a crossover dietary intervention that included three 8-week, isoenergetic diet treatments. The treatments consisted of high fat (40% of energy as fat), low fat (20% of energy), and low fat + n-3 fatty acids (20% of energy plus 3% as n-3 fatty acids). Eight subjects were homozygous for the wild type (Ala54/Ala54) of the FABP2 polymorphism, whereas 8 subjects had at least 1 Thr54 allele (7, Ala54/Thr54; 1, Thr54/Thr54). High-fat diet showed significantly reduced plasma TGs, chylomicron TG, and very low-density lipoprotein TG from baseline in all participants. Although carriers of the Thr54 allele of the FABP2 polymorphism had significantly reduced TRL, there is no evidence of an interaction, which does not support our hypothesis. The alanine-encoding allele did not influence the dietary effects on the plasma lipids. |
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Authors:
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Steven P McColley; Angeliki Georgopoulos; Lindsay R Young; Mindy S Kurzer; J Bruce Redmon; Susan K Raatz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 31 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 503-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Food Science and Nutrition at the University of Minnesota, Minneapolis, MN 55455, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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