| A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. | |
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MedLine Citation:
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PMID: 20670674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is a growing global health problem that contributes to diabetes, hypertension, cardiovascular diseases, dementia, and cancer. The increased consumption of saturated fats in a high-fat diet (HFD) contributes to obesity, neurodegenerative diseases, long-term memory loss, and cognitive impairment. We tested whether HFD influences adult hippocampal neurogenesis. Male C57BL/6 mice were divided into two groups and maintained on either a normal diet (ND) or HFD. Seven weeks of HFD significantly decreased the numbers of newly generated cells in the dentate gyrus of the hippocampus without neuronal loss. HFD also increased the level of malondialdehyde (MDA) and decreased the level of brain-derived neurotrophic factor (BDNF) in the hippocampus. The toxic effects of MDA were evaluated on neural progenitor cells (NPCs). MDA reduced the growth of NPCs, but BDNF treatment restored NPCs proliferation. The present data indicate that a HFD impairs hippocampal neurogenesis and NPCs proliferation through increased lipid peroxidation and decreased BDNF. |
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Authors:
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Hee Ra Park; Mikyung Park; Jehun Choi; Kun-Young Park; Hae Young Chung; Jaewon Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-27 |
Journal Detail:
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Title: Neuroscience letters Volume: 482 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-26 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 235-9 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong-gu, Busan 609-735, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain-Derived Neurotrophic Factor / biosynthesis* Dietary Fats / adverse effects* Hippocampus / cytology, metabolism* Immunohistochemistry Lipid Peroxidation / physiology* Male Mice Mice, Inbred C57BL Neural Stem Cells / cytology, metabolism* Neurogenesis / physiology* Obesity / etiology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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