Document Detail

A hierarchical modeling approach of hippocampus local circuit.
MedLine Citation:
PMID:  19412980     Owner:  NLM     Status:  MEDLINE    
The modeling and simulation of a realistic nervous tissue are difficult because of the number of implied cell types (neuronal and glial), the topology of the networks, and the various heterogeneous molecular mechanisms. The MTIP (Mathematical Theory of Integrative Physiology) is used as a new modeling approach based on a representation in terms of functional interactions and a formalism (S-Propagator) related to n-level field theory. This work presents the passage from a theoretical description of the biological system to a computing implementation in the general case. The specific case of the hippocampus is presented, as well as how a drug allows learning and memory improvement in the local circuit of the CA1 area of the hippocampus. This in silico result is used to experimentally predict the drug effect in vitro to confirm the accuracy of MTIP.
Omar Bennani; Gilbert Chauvet; Pierre Chauvet; Jean-Marc Dupont; Francois Jouen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of integrative neuroscience     Volume:  8     ISSN:  0219-6352     ISO Abbreviation:  J. Integr. Neurosci.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156357     Medline TA:  J Integr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-76     Citation Subset:  IM    
CHArt, Ecole Pratique des Hautes Etudes, 41 rue Gay-Lussac Paris, 75005, France.
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MeSH Terms
Hippocampus / cytology,  physiology*
Models, Neurological*
Nerve Net / cytology,  physiology*
Neural Networks (Computer)
Neural Pathways / physiology
Neuronal Plasticity / physiology
Neurons / physiology*

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