| The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-fetal tolerance. | |
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MedLine Citation:
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PMID: 19876825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genetic disparity between the mother and fetus has long enticed immunologists to search for mechanisms of maternal tolerance to fetal antigens. The study of antigen-specific tolerance in murine and human pregnancy has gained new momentum in recent years through the focus on antigen-presenting cells, uterine lymphatics and fetal antigen-specific maternal T cell responses. In mice, we now know that these responses occur within the secondary lymphoid structures as they can be conveniently tracked through the use of defined, often transgenic fetal antigens and maternal T cell receptors. Although the secondary lymphoid organs are sites of both immunization and tolerization to antigens, the immunological processes that occur in response to fetal antigens during the healthy pregnancy must invariably lead to tolerance. The molecular properties of these maternal-fetal tolerogenic interactions are still being unraveled, and are likely to be greatly influenced by tissue-specific microenvironments and the hormonal milieu of pregnancy. In this article, we discuss the events leading to antigen-specific maternal tolerance, including the trafficking of fetal antigens to secondary lymphoid organs, the properties of the antigen-presenting cells that display them to maternal T lymphocytes, and the nature of the ensuing tolerogenic response. Experimental data generated from human biological specimens as well as murine transgenic models are considered. |
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Authors:
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Elizabeth S Taglauer; Kristina M Adams Waldorf; Margaret G Petroff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The International journal of developmental biology Volume: 54 ISSN: 1696-3547 ISO Abbreviation: Int. J. Dev. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-08 Completed Date: 2010-03-31 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8917470 Medline TA: Int J Dev Biol Country: Spain |
Other Details:
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Languages: eng Pagination: 421-30 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dendritic Cells / immunology Female Fetal Proteins / immunology Histocompatibility / immunology Histocompatibility, Maternal-Fetal / immunology* Humans Immune Tolerance / immunology* Lymph Nodes / immunology* Lymphocytes / immunology Maternal-Fetal Exchange / immunology* Mice Placenta / immunology Pregnancy Spleen / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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K08 AI067910/AI/NIAID NIH HHS; K08 AI067910-03/AI/NIAID NIH HHS; P01 HD049480-020003/HD/NICHD NIH HHS; P01HD049480/HD/NICHD NIH HHS; R01 HD045611/HD/NICHD NIH HHS; R01 HD045611-06/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fetal Proteins |
| Comments/Corrections | |
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