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A heuristic algorithm for haplotype reconstruction from aligned weighted SNP fragments.
MedLine Citation:
PMID:  23207995     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Haplotyping problem has been the subject of extensive research in recent years, and is one of the hottest areas of Computational Biology today. In this paper, we study the single individual Single Nucleotide Polymorphism (SNP) haplotype reconstruction problem. A heuristic algorithm is proposed for assembling a pair of haplotypes from a set of aligned weighted SNP fragments. Computational experiments indicate that the algorithm is a good solution for the Weighted Minimum Letter Flips (WMLF) model, and gets better performance than previous works.
Authors:
Jingli Wu; Jianxin Wang; Jian'er Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of bioinformatics research and applications     Volume:  9     ISSN:  1744-5485     ISO Abbreviation:  Int J Bioinform Res Appl     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253758     Medline TA:  Int J Bioinform Res Appl     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  13-24     Citation Subset:  IM    
Affiliation:
School of Information Science and Engineering, Central South University, Changsha, 410083, China; Department of Computer Science, Guangxi Normal University, Guilin, 541004, China.
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