Document Detail

The heritability of blood pressure: an investigation of 200 pairs of twins using the cold pressor test.
MedLine Citation:
PMID:  1167918     Owner:  NLM     Status:  MEDLINE    
Blood pressures in 200 pairs of twins having a mean age of 14.0 (S.D. equals 6.5) years were measured at basal levels and in response to the cold pressor test. Intraclass correlations were consistently larger (and intrapair variances consistently smaller) in monozygotic as compared to dizygotic pairs, substantially more so in females than in males. Sex differences in heritability were somewhate greater for systolic than for diastolic blood pressure. Indices of heritability (H) at basal levels were, in descending order: 0.78 (female systolic), 0.61 (female diastolic), 0.56 (male diastolic), and 0.41 (male systolic). The same descending order for H was found for blood pressure responses to the cold pressor test. It is concluded that in the population studied, genetic factors play an important role in the control of blood pressure over the normal range of vascular reactivity. In females, such factors may be the major determinant of the variability observed.
M L McIlhany; J W Shaffer; E A Hines
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Johns Hopkins medical journal     Volume:  136     ISSN:  0021-7263     ISO Abbreviation:  Johns Hopkins Med J     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-06-06     Completed Date:  1975-06-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0072456     Medline TA:  Johns Hopkins Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Child, Preschool
Cold Temperature / diagnostic use*
Genetics, Medical*
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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