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The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress.
MedLine Citation:
PMID:  22034909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Mitochondrial adenine nucleotide translocator (ANT) plays important roles in the regulation of mitochondrial permeability transition and cell bioenergetics. The mouse has three ANT isoforms (1, 2 and 4) showing tissue-specific expression patterns. Although ANT1 is known to have a pro-apoptotic property, the specific functions of ANT2 have not been well determined. In the present study, ANT2 expression was significantly lower in the aged rat liver and in a liver fibrosis model. To explore the protective role of ANT2 in the liver, we established a hepa1c1c7 cell line overexpressing ANT2. Overexpression of ANT2 caused hepa1c1c7 cells to be more resistance to oxidative stress, and mitochondrial membrane potential (MMP, ΔΨm) was relatively intact in ANT2-overexpressing cells under oxidative stress. In addition, ANT2 was found to increase ATP production by influencing mitochondrial bioenergetics. These results imply that the hepatoprotective effect of ANT2 is due to the stabilization of MMP and enhanced ATP production, and thus, maintaining ANT2 levels in the liver might be important to enhance resistance to aging and oxidative stress.
Authors:
Hyun Soo Kim; Jeong Hwan Je; Tae Gen Son; Hee Ra Park; Seung Taek Ji; Yuba Raj Pokharel; Hyun Min Jeon; Keon Wook Kang; Ho Sung Kang; Seung-Cheol Chang; Hyung Sik Kim; Hae Young Chung; Jaewon Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-31
Journal Detail:
Title:  Free radical research     Volume:  -     ISSN:  1029-2470     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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