Document Detail

The hepatoprotective effect of oxygen during halothane anesthesia.
MedLine Citation:
PMID:  360877     Owner:  NLM     Status:  MEDLINE    
The effects of halothane anesthesia on liver function, as reflected by postanesthetic changes in serum glutamic pyruvic transaminase (SGPT) levels, were evaluated in 2 groups of 40 patients. All patients had 2 halothane anesthetics. In 1 group, both anesthetics were administered at 1 atmosphere pressure with 30% O2 in the inspired air. In the 2nd group, both anesthetics were administered at 2 to 3 atmospheres (absolute) of pressure with 97 to 98% O2 in the inspired air. While the SGPT levels remained within the normal range in all cases, there was a significant rise in SGPT levels in patients undergoing surgery under 1 atmospheric pressure. Patients undergoing surgery at 2 to 3 atmospheres pressure (absolute) had SGPT levels which remained at low normal values. The difference in response of SGPT in the 2 groups was statistically significant. We conclude that increased O2 tensions alter the normal response of SGPT to halothane anesthesia and that increased O2 tensions appear to protect the liver from possible adverse responses to halothane or its metabolites.
V Pratilas; M G Pratila; J Bramis; H Smith
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  57     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1978 Jul-Aug
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  AIM; IM    
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MeSH Terms
Alanine Transaminase / blood
Anesthesia, Inhalation*
Clinical Trials as Topic
Halothane / adverse effects*
Hyperbaric Oxygenation*
Liver / drug effects*
Middle Aged
Reg. No./Substance:
151-67-7/Halothane; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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