Document Detail

Is hepatitis A vaccination necessary in Indian patients with cirrhosis of liver?
MedLine Citation:
PMID:  12696823     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Hepatitis A vaccine has been recommended for patients with chronic liver disease since they have high mortality following acute hepatitis. This study was done to assess the prevalence of antibodies to hepatitis A virus in Indian patients with liver cirrhosis to determine the relevance of this recommendation in India. METHODS: Consecutive patients with cirrhosis of liver seen at two referral hospitals in southern India were tested for antibodies to hepatitis A virus using EIA. Age-matched non-cirrhotic adults attending the OPD served as controls. RESULTS: Of the 52 patients (mean [SD] age 57.1 [11.0] years; 33 men) and 50 control subjects (52.0 [14.8] 5 years; 39 men), 51 patients and all the controls tested positive (p=ns). CONCLUSION: Most patients with liver cirrhosis have antibodies against hepatitis A virus and thus immunization against this infection without screening appears unnecessary in them.
Saju Xavier; K Anish
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  22     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-04-16     Completed Date:  2003-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  54-5     Citation Subset:  IM    
Al shifa Hospital, Perintalmanna, Kerala 679 322.
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MeSH Terms
Hepatitis A / complications,  prevention & control
Hepatitis A Antibodies / analysis*
Liver Cirrhosis / complications*,  immunology
Middle Aged
Seroepidemiologic Studies
Vaccination / utilization
Reg. No./Substance:
0/Hepatitis A Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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