Document Detail


Is heparin a placental anticoagulant in high-risk pregnancies?
MedLine Citation:
PMID:  21868576     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Randomized control trials demonstrate beneficial effects of heparin in high-risk pregnancies to prevent pre-eclampsia and intrauterine growth restriction. However the lack of placental pathology data in these trials challenges the assumption that heparin is a placental anticoagulant. Recent data demonstrates that placental infarction is more likely to be associated with abnormalities in development of the placenta, characterized by poor maternal perfusion and an abnormal villous trophoblast compartment in contact with maternal blood, than with maternal thrombophilia. At-risk pregnancies may therefore be predicted by non-invasive prenatal testing of placental function in mid-pregnancy. Heparin has diverse cellular functions that include direct actions on trophoblast. Dissecting the non-anti-coagulant actions of heparin may reveal novel and safer therapeutic targets to prevent the major placental complications of pregnancy.
Authors:
John C P Kingdom; Sascha Drewlo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-25
Journal Detail:
Title:  Blood     Volume:  -     ISSN:  1528-0020     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Maternal-Fetal Medicine Division, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, Toronto, ON, Canada;
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