| Is heparin a placental anticoagulant in high-risk pregnancies? | |
| | |
MedLine Citation:
|
PMID: 21868576 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Randomized control trials demonstrate beneficial effects of heparin in high-risk pregnancies to prevent pre-eclampsia and intrauterine growth restriction. However the lack of placental pathology data in these trials challenges the assumption that heparin is a placental anticoagulant. Recent data demonstrates that placental infarction is more likely to be associated with abnormalities in development of the placenta, characterized by poor maternal perfusion and an abnormal villous trophoblast compartment in contact with maternal blood, than with maternal thrombophilia. At-risk pregnancies may therefore be predicted by non-invasive prenatal testing of placental function in mid-pregnancy. Heparin has diverse cellular functions that include direct actions on trophoblast. Dissecting the non-anti-coagulant actions of heparin may reveal novel and safer therapeutic targets to prevent the major placental complications of pregnancy. |
| | |
Authors:
|
John C P Kingdom; Sascha Drewlo |
Related Documents
:
|
1543826 - Medical disorders in pregnancy. 8620086 - Ultrasound features of normal early pregnancy development. 8583596 - Diagnosis and treatment of ureteral calculi during pregnancy with rigid ureteroscopes. 3150396 - Application of ultrasound in the diagnosis of heterotopic pregnancy--a review of the li... 3347446 - Ehlers-danlos syndrome type iii in pregnancy. 6788606 - Observations on the combination of clomiphene citrate-human menopausal gonadotropin-hum... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-25 |
Journal Detail:
|
Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Maternal-Fetal Medicine Division, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, Toronto, ON, Canada; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse larg...
Next Document: Donor immunization with WT1 peptide augments anti-leukemic activity after MHC-matched bone marrow tr...